Research Interests

My lab uses molecular, cellular, and biochemical approaches to investigate basic mechanisms of DNA mutagenesis and genomic instability. Genome maintenance pathways ensure the faithful DNA replication, repair, and targeted mutagenesis of DNA. The misregulation such processes promote genome instability that leads to immunodeficiency and cancer-causing DNA damage. Ongoing research projects include the microRNA regulations governing expression of DNA mutators in human epithelial cancers, the chromatin modifications associated with mutagenic targeting in B cell lymphomas, formation and metabolism of quadruplex DNA, and the activity of the DNA repair enzyme Endonuclease V. Students at all levels (undergraduate, Masters, and PhD) contribute to the current research output from my lab, and inquiries into open student research positions are welcome.