Welcome to the School of Biological Sciences

School of Biological Sciences



David A. Rubin

Associate Professor

Office Address: SLB 254
Office Phone: (309) 438-3669
Office Hours:
Email: Contact David Rubin (adavid)
Website: Visit David Rubin’s Website
Teaching Schedule:
Course NumberSectionCourse NameTimeRoom NumberCourse Links
BSC305.01Biological Evolution   
Research Interests:

Selected Publications:

Hester PY,  Enneking SA, Haley BK, Cheng HW, Einstein ME, and Rubin DA. 2013.  The effect of perch availability during pullet rearing and egg laying on musculoskeletal health of caged White Leghorn hens.  Poultry Sci. 92(8):1972-1980.   

Hester PY,  Enneking SA, Jefferson-Moore KY, Einstein ME, Cheng HW and Rubin DA.  2013.  The effect of perches in cages during pullet rearing and egg laying on White Leghorn hen performance, foot health, and plumage.   Poultry Sci. 92(2):310-320. 

Filshtein TJ, Mackenzie CO, Dale MD, Dela-Cruz PS, Ernst DM, Frankenberger EA, HE C, Heath KL, Jones AS, Jones DK, King ER, Maher MB, Mitchell TJ, Morgan RR, Sirobhushanam S, Halkyard SD, Tiwari KB, Rubin DA, Borchert GM and Larson ED. 2012. OrbID: Origin-based identification of microRNA targets. Mobile Genetic Elements 2(3):1-9. 

Enneking SA, Cheng HW, Jefferson-Moore KY, Einstein ME, Rubin DA, and Hester PY.  2012. Early access to perches in caged White Leghorn pullets.  Poult Sci. 91(9):2114-2120.  

Yan YL, Bhattacharya P, He XJ, Ponugoti B, Marquardt B, Layman J, Grunloh M, Postlethwait JH and Rubin DA.  2012.  Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis.  J Endocrinol. 214(3):421-435.  

Bhattacharya P, Yan YL, Postlethwait J, Rubin DA. 2011.  Evolution of the vertebrate pth2 (tip39) gene family and the regulation of PTH type 2 receptor (pth2r) and its endogenous ligand pth2 by hedgehog signaling in zebrafish development. J Endocrinol. 211(2):187-200

Shoemaker JM, Riley LG, Hirano T, Grau EG, Rubin DA. 2006. Differential expression of tuberoinfundibular peptide 38 and glucose-6-phosphatase in tilapia. Gen Comp Endocrinol. 2006 Apr;146(2):186-94

Papasani MR, Gensure RC, Yan YL, Gunes Y, Postlethwait JH, Ponugoti B, John MR, Jüppner H, Rubin DA.  2004. Identification and characterization of the zebrafish and fugu genes encoding tuberoinfundibular peptide 39.  Endocrinology. 2004 Nov;145(11):5294-304

Gensure RC, Ponugoti B, Gunes Y, Papasani MR, Lanske B, Bastepe M, Rubin DA, Jüppner H. 2004.  Identification and characterization of two parathyroid hormone-like molecules in zebrafish.  Endocrinology. 2004 Apr;145(4):1634-9.

John MR, Arai M, Rubin DA, Jonsson KB, Jüppner H. 2002.  Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002 Mar;143(3):1047-57.

Hoare SR, Rubin DA, Jüppner H, Usdin TB. 2000.  Evaluating the ligand specificity of zebrafish parathyroid hormone (PTH) receptors: comparison of PTH, PTH-related protein, and tuberoinfundibular peptide of 39 residues. Endocrinology. 2000 Sep;141(9):3080-6.

Rubin DA, Jüppner H. 1999. Zebrafish express the common parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) and a novel receptor (PTH3R) that is preferentially activated by mammalian and fugufish parathyroid hormone-related peptide. J Biol Chem. 1999 Oct 1;274(40):28185-90.

Rubin DA, Hellman P, Zon LI, Lobb CJ, Bergwitz C, Jüppner H. 1999. A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones. J Biol Chem. 1999 Aug 13;274(33):23035-42.

Bergwitz C, Klein P, Kohno H, Forman SA, Lee K, Rubin D, Jüppner H. 1998. Identification, functional characterization, and developmental expression of two nonallelic parathyroid hormone (PTH)/PTH-related peptide receptor isoforms in Xenopus laevis (Daudin). Endocrinology. 1998 Feb;139(2):723-32.

Dores RM, Smith TR, Rubin DA, Danielson P, Marra LE, Youson JH. 1997. Deciphering posttranslational processing events in the pituitary of a neopterygian fish: cloning of a gar proopiomelanocortin cDNA. Gen Comp Endocrinol. 1997 Sep;107(3):401-13.

Dores RM, Rubin DA, Quinn TW. 1996. Is it possible to construct phylogenetic trees using polypeptide hormone sequences? Gen Comp Endocrinol. 1996 Jul;103(1):1-12. Review.

Rubin DA, Dores RM. 1995. Obtaining a more resolute teleost growth hormone phylogeny by the introduction of gaps in sequence alignment.  Mol Phylogenet Evol. 4(2):129-38.

Rubin DA, Dores RM. 1994.  Cloning of a growth hormone from a primitive bony fish and its phylogenetic relationships. Gen Comp Endocrinol.  95(1):71-83

Keutmann HT and Rubin DA 1993. A subunit interaction site in human luteinizing hormone: identification by photoaffinity cross-linking. Endocrinology 132(3):1305-12 

Dores RM, McDonald LK, Goldsmith A, Deviche P, and Rubin DA.  1993.  The phylogeny of enkephalins:  Speculations on the origins of opioid precursors.  Cell. Physiol. Biochem. 3(3):231-244. 

Rubin DA and Specker JL 1992.  In vitro effects of homologous prolactins on testosterone production by testes of tilapia (Oreochromis mossambicus). Gen Comp Endocrinol. 87(2):189-96

Gardella TJ, Axelrod D, Rubin D, Keutmann HT, Potts JT Jr, Kronenberg HM, Nussbaum SR. 1991. Mutational analysis of the receptor-activating region of human parathyroid hormone. J Biol Chem. 266(20):13141-6.

Gardella TJ, Rubin D, Abou-Samra AB, Keutmann HT, Potts JT Jr, Kronenberg HM, Nussbaum SR. 1990. Expression of human parathyroid hormone-(1-84) in Escherichia coli as a factor X-cleavable fusion protein. J Biol Chem. 265(26):15854-9.

Rubin DA 1985.  Effect of pH on sex ratio in Cichlids and a Poeciliid (Teleostei) Copeia, Vol. 1985, No. 1 (Feb. 11, 1985), pp. 233-235